Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Identifieur interne : 000019 ( France/Analysis ); précédent : 000018; suivant : 000020Subthalamic neuronal firing in obsessive‐compulsive disorder and Parkinson disease
Auteurs : Brigitte Piallat [France] ; Mircea Polosan [France] ; Valérie Fraix [France] ; Laurent Goetz [France] ; Olivier David [France] ; Albert Fenoy [France] ; Napoleon Torres [France] ; Jean-Louis Quesada [France] ; Eric Seigneuret [France] ; Pierre Pollak [France] ; Paul Krack [France] ; Thierry Bougerol [France] ; Alim-Louis Benabid [France] ; Stéphan Chabardès [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Abstract
Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive‐compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive‐compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left‐sided in obsessive‐compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive‐compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left‐sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. Ann Neurol 2010.
Url:
DOI: 10.1002/ana.22222
Affiliations:
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sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Psychiatry, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Atomic Energy Commission of Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Grenoble University</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM‐U836, Grenoble Institute of Neurosciences</wicri:regionArea><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion><wicri:noRegion>Grenoble Institute of Neurosciences</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, University Hospital of Grenoble</wicri:regionArea><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion><wicri:noRegion>University Hospital of Grenoble</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="793">793</biblScope><biblScope unit="page" to="802">802</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">D181E3C67D96B43C1EFC13A3E1D51CBFE627F9B9</idno><idno type="DOI">10.1002/ana.22222</idno><idno type="ArticleID">ANA22222</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high‐frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive‐compulsive disorder. Methods: We compared the neuronal activity of the subthalamic nucleus recorded in 9 patients with obsessive‐compulsive disorder with that of 11 patients with Parkinson disease measured during intraoperative exploration for deep brain stimulation. Results: The mean subthalamic neuron discharge rate was statistically lower in patients with obsessive‐compulsive disorder than in patients with Parkinson disease (20.5 ± 11.0 Hz, n = 100 and 30.8 ± 15.6 Hz, n = 93, respectively, p < 0.001). The relative proportion of burst neurons did not differ significantly between the 2 diseases (75% vs 73%). Interestingly, burst neurons were predominantly left‐sided in obsessive‐compulsive disorder. Interpretation: The recording of burst neurons within the nonmotor subthalamic nucleus in patients with obsessive‐compulsive disorder is a novel finding that suggests the existence of deregulation of the nonmotor basal ganglia loop, possibly left‐sided. Potentially, burst activity might interfere with normal processes occurring within nonmotor loops. Ann Neurol 2010.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name></noRegion><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><name sortKey="Bougerol, Thierry" sort="Bougerol, Thierry" uniqKey="Bougerol T" first="Thierry" last="Bougerol">Thierry Bougerol</name><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stéphan" last="Chabardès">Stéphan Chabardès</name><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><name sortKey="David, Olivier" sort="David, Olivier" uniqKey="David O" first="Olivier" last="David">Olivier David</name><name sortKey="Fenoy, Albert" sort="Fenoy, Albert" uniqKey="Fenoy A" first="Albert" last="Fenoy">Albert Fenoy</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name><name sortKey="Polosan, Mircea" sort="Polosan, Mircea" uniqKey="Polosan M" first="Mircea" last="Polosan">Mircea Polosan</name><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><name sortKey="Quesada, Jean Ouis" sort="Quesada, Jean Ouis" uniqKey="Quesada J" first="Jean-Louis" last="Quesada">Jean-Louis Quesada</name><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><name sortKey="Seigneuret, Eric" sort="Seigneuret, Eric" uniqKey="Seigneuret E" first="Eric" last="Seigneuret">Eric Seigneuret</name><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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